Abstract:

Melphalan is the most effective drug in curing retinoblastoma (RB) currently. At present, the mainstream drug delivery mode is intraarterial chemotherapy and intravitreal injection. No adverse events happened in 70% of the patients who received intraarterial chemotherapy within two years. Because there has been hardly any systemic toxicity reported, intraarterial chemotherapy of melphalan is now widely used. Curing vitreous seeds is the most challenging part in the treatment of RB. However, when the technic of intravitreal injection of melphalan appears, the eyeball salvage rate of RB with vitreous seeds is surpassing any of the treating methods before. Therefore, intraarterial chemotherapy and intravitreal injection of melphalan are safe and effective ways to cure RB.